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FIGURE 1 | Effects of OA (20 μM) on the expression of UGT1A1 (A, B), <t>HSP90α</t> (B), PKCα (C), PXR (D) and SRC1 (E) in HepG2 cells. The data are presented as the mean ± SD of triplicate independent experiments. *p < 0.05, **p < 0.01 and ***p < 0.001 compare to control group; #p < 0.05 and
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FIGURE 1 | Effects of OA (20 μM) on the expression of UGT1A1 (A, B), HSP90α (B), PKCα (C), PXR (D) and SRC1 (E) in HepG2 cells. The data are presented as the mean ± SD of triplicate independent experiments. *p < 0.05, **p < 0.01 and ***p < 0.001 compare to control group; #p < 0.05 and

Journal: Phytotherapy research : PTR

Article Title: Oleanolic Acid Up-Regulated UGT1A1 and Antagonized Inflammation by Affecting the Binding of PXR and PKCα to HSP90α and SRC1.

doi: 10.1002/ptr.8515

Figure Lengend Snippet: FIGURE 1 | Effects of OA (20 μM) on the expression of UGT1A1 (A, B), HSP90α (B), PKCα (C), PXR (D) and SRC1 (E) in HepG2 cells. The data are presented as the mean ± SD of triplicate independent experiments. *p < 0.05, **p < 0.01 and ***p < 0.001 compare to control group; #p < 0.05 and

Article Snippet: PXR (mouse- monoclonal, sc- 48403, Lot: A1819), HSP90α (mouse- monoclonal, sc- 13119, Lot: D2523) and PKCα (mousemonoclonal, sc- 8393, Lot: C2219) were obtained from Santa Cruz Biotechnology Co. Ltd. (Santa Cruz, CA, USA).

Techniques: Expressing, Control

FIGURE 2 | Effects of OA (20 μM) on the PKCα pull-down protein expression of HSP90α (A, B), PXR pull-down protein expression of SRC1 (C, D) and HSP90α (C, E) in HepG2 cells. The data are presented as the mean ± SD of triplicate independent experiments. *p < 0.05, **p < 0.01 and ***p < 0.001 compare to control group; #p < 0.05 and ##p < 0.01 compare to PMA treated group, respectively.

Journal: Phytotherapy research : PTR

Article Title: Oleanolic Acid Up-Regulated UGT1A1 and Antagonized Inflammation by Affecting the Binding of PXR and PKCα to HSP90α and SRC1.

doi: 10.1002/ptr.8515

Figure Lengend Snippet: FIGURE 2 | Effects of OA (20 μM) on the PKCα pull-down protein expression of HSP90α (A, B), PXR pull-down protein expression of SRC1 (C, D) and HSP90α (C, E) in HepG2 cells. The data are presented as the mean ± SD of triplicate independent experiments. *p < 0.05, **p < 0.01 and ***p < 0.001 compare to control group; #p < 0.05 and ##p < 0.01 compare to PMA treated group, respectively.

Article Snippet: PXR (mouse- monoclonal, sc- 48403, Lot: A1819), HSP90α (mouse- monoclonal, sc- 13119, Lot: D2523) and PKCα (mousemonoclonal, sc- 8393, Lot: C2219) were obtained from Santa Cruz Biotechnology Co. Ltd. (Santa Cruz, CA, USA).

Techniques: Expressing, Control

FIGURE 3 | Effects of OA (20 μM) on the localization of PKCα and HSP90α (A), PXR and HSP90α (B), PXR and SRC1 (C) in HepG2 cells and the structure of compound OA (D).

Journal: Phytotherapy research : PTR

Article Title: Oleanolic Acid Up-Regulated UGT1A1 and Antagonized Inflammation by Affecting the Binding of PXR and PKCα to HSP90α and SRC1.

doi: 10.1002/ptr.8515

Figure Lengend Snippet: FIGURE 3 | Effects of OA (20 μM) on the localization of PKCα and HSP90α (A), PXR and HSP90α (B), PXR and SRC1 (C) in HepG2 cells and the structure of compound OA (D).

Article Snippet: PXR (mouse- monoclonal, sc- 48403, Lot: A1819), HSP90α (mouse- monoclonal, sc- 13119, Lot: D2523) and PKCα (mousemonoclonal, sc- 8393, Lot: C2219) were obtained from Santa Cruz Biotechnology Co. Ltd. (Santa Cruz, CA, USA).

Techniques:

FIGURE 6 | Effects of OA (20 μM) on the PKCα pull-down protein expression of HSP90α (A, B), PXR pull-down protein expression of SRC1 (C, D) and HSP90α (C, E) in HepG2 cells overexpressing hPKCα. The data are presented as the mean ± SD of triplicate independent experiments. *p < 0.05, **p < 0.01 and ***p < 0.001 compare to control group; #p < 0.05, ##p < 0.01 and ###p < 0.001 compare to hPKCα OE group, respectively.

Journal: Phytotherapy research : PTR

Article Title: Oleanolic Acid Up-Regulated UGT1A1 and Antagonized Inflammation by Affecting the Binding of PXR and PKCα to HSP90α and SRC1.

doi: 10.1002/ptr.8515

Figure Lengend Snippet: FIGURE 6 | Effects of OA (20 μM) on the PKCα pull-down protein expression of HSP90α (A, B), PXR pull-down protein expression of SRC1 (C, D) and HSP90α (C, E) in HepG2 cells overexpressing hPKCα. The data are presented as the mean ± SD of triplicate independent experiments. *p < 0.05, **p < 0.01 and ***p < 0.001 compare to control group; #p < 0.05, ##p < 0.01 and ###p < 0.001 compare to hPKCα OE group, respectively.

Article Snippet: PXR (mouse- monoclonal, sc- 48403, Lot: A1819), HSP90α (mouse- monoclonal, sc- 13119, Lot: D2523) and PKCα (mousemonoclonal, sc- 8393, Lot: C2219) were obtained from Santa Cruz Biotechnology Co. Ltd. (Santa Cruz, CA, USA).

Techniques: Expressing, Control